Topiramate | B3280

Topiramate is a potent antiepileptic drug with a broad spectrum of activity. Topiramate acts as an antagonist of GluK1 kainate receptors (IC50 = 0.46 μM); also acts as a positive allosteric modulator of GABAA receptor-mediated currents, inhibits Nav channels (IC50 = 48.9 μM) and inhibits L-type Ca2+ channels. Also inhibits carbonic anhydrase (CA) (Ki values are 0.1 and 0.2 μM at rat CA II and CA IV respectively), which lowers intracellular neuronal pH.

Topiramate is a potent antiepileptic drug with a broad spectrum of activity. Topiramate acts as an antagonist of GluK1 kainate receptors (IC50 = 0.46 μM); also acts as a positive allosteric modulator of GABAA receptor-mediated currents, inhibits Nav channels (IC50 = 48.9 μM) and inhibits L-type Ca2+ channels. Also inhibits carbonic anhydrase (CA) (Ki values are 0.1 and 0.2 μM at rat CA II and CA IV respectively), which lowers intracellular neuronal pH.

B3280 | Topiramate DataSheet

Alternate Name/Synonyms: 2,3:4,5-Bis-O-(1-methylethylidene)-β-D-fructopyranose sulfamate

Appearance: White solid

Formulation:

CAS Number: 97240-79-4

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₂H₂₁NO₈S

Molecular Weight: 339.36

Cell-Permeable?: True

Purity: ≥98% by HPLC

Solubilities:

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: An anticonvulsant and an antagonist of GluK1 kainate receptors

MDL Number: MFCD00865320

PubChem CID: 5284627

SMILES: CC(O2)(C)O[C@H]1[C@@H]2[C@H](OC(C)(C)O3)[C@@]3(COS(N)(=O)=O)OC1

InChi: InChI=1S/C12H21NO8S/c1-10(2)18-7-5-16-12(6-17-22(13,14)15)9(8(7)19-10)20-11(3,4)21-12/h7-9H,5-6H2,1-4H3,(H2,13,14,15)/t7-,8-,9+,12+/m1/s1

InChi Key: KJADKKWYZYXHBB-XBWDGYHZSA-N