Topotecan hydrochloride | B2050

Topocecan is a semisynthetic derivative of Camptothecin (Cat.No.1039) that displays antineoplastic activity. DNA topoisomerase I inhibitor; induces rapid apoptotic death in human B-lineage acute lymphoblastic leukemia (ALL) cells. Improves survival in three mouse models of poor prognosis.

Topocecan is a semisynthetic derivative of Camptothecin (Cat.No.1039) that displays antineoplastic activity. DNA topoisomerase I inhibitor; induces rapid apoptotic death in human B-lineage acute lymphoblastic leukemia (ALL) cells. Improves survival in three mouse models of poor prognosis.

B2050 | Topotecan hydrochloride DataSheet

Alternate Name/Synonyms: 10-[(Dimethylamino)methyl]-4-ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione hydrochloride

Appearance: Yellow solid

Formulation: N/A

CAS Number: 119413-54-6

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₃H₂₃N₃O₅.HCl

Molecular Weight: 457.91

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (>40 mg/ml) or H2O (>40 mg/ml)

Handling: Protect from air and moisture

Country of Origin: USA

Tag Line: A DNA topoisomerase I inhibitor

MDL Number: N/A

PubChem CID: 60699

SMILES: CCC1(C2=C(COC1=O)C(=O)N3CC4=C(C3=C2)N=C5C=CC(=C(C5=C4)CN(C)C)O)O.Cl

InChi: InChI=1S/C23H23N3O5.ClH/c1-4-23(30)16-8-18-20-12(9-26(18)21(28)15(16)11-31-22(23)29)7-13-14(10-25(2)3)19(27)6-5-17(13)24-20;/h5-8,27,30H,4,9-11H2,1-3H3;1H/t23-;/m0./s1

InChi Key: DGHHQBMTXTWTJV-BQAIUKQQSA-N