Description
TP-0903 is a potent and selective AXL Inhibitor (IC₅₀ = 27 nM). TP-0903 induces massive apoptosis in CLL B cells with LD₅₀ values of nanomolar ranges. Treatment of cancer cells with TP-0903 reverses the mesenchymal phenotype in multiple models and sensitizes cancer cells to treatment with other targeted agents.
TP-0903 is a potent and selective AXL Inhibitor (IC₅₀ = 27 nM). TP-0903 induces massive apoptosis in CLL B cells with LD₅₀ values of nanomolar ranges. Treatment of cancer cells with TP-0903 reverses the mesenchymal phenotype in multiple models and sensitizes cancer cells to treatment with other targeted agents.
Alternate Name/Synonyms: 2-((5-chloro-2-((4-((4-methylpiperazin-1-yl)methyl)phenyl)amino)pyrimidin-4-yl)amino)-N,N-dimethylbenzenesulfonamide
Appearance: White solid
Formulation: N/A
CAS Number: 1341200-45-0
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₂₄H₃₀ClN₇O₂S
Molecular Weight: 516.06
Cell-Permeable?: Yes
Purity: ≥98% by HPLC
Solubilities: DMSO (>5 mg/ml)
Handling: Protect from air and light
Country of Origin: USA
Tag Line: A potent and selective AXL kinase Inhibitor
MDL Number: N/A
PubChem CID: 56839178
SMILES: CN1CCN(CC1)CC2=CC=C(C=C2)NC3=NC=C(C(=N3)NC4=CC=CC=C4S(=O)(=O)N(C)C)Cl
InChi: InChI=1S/C24H30ClN7O2S/c1-30(2)35(33,34)22-7-5-4-6-21(22)28-23-20(25)16-26-24(29-23)27-19-10-8-18(9-11-19)17-32-14-12-31(3)13-15-32/h4-11,16H,12-15,17H2,1-3H3,(H2,26,27,28,29)
InChi Key: YUAALFPUEOYPNX-UHFFFAOYSA-N
Additional Information
Storage Condition: |
-20°C |
Shipping Condition: |
Gel Pack |
Shelf Life: |
36 months |