TPCA-1 | 2431

A potent and selective inhibitor of IκB kinase-2 (IKK-2) (IC₅₀ = 17.9 nM). Displays > 22-fold selectivity over IKK-1 and > 550-fold selectivity over other kinases and enzymes. TPCA-1 inhibits production of pro-inflammatory cytokines in vitro and in vivo and inhibits NF-κB nuclear localization. It has been used to study inhibition of IKK-2 to prevent inflammatory mediator release in animal models of arthritis and airway inflammation.

TPCA-1 is a potent and selective inhibitor of IκB kinase-2 (IKK-2) (IC₅₀ = 17.9 nM). Displays > 22-fold selectivity over IKK-1 and > 550-fold selectivity over other kinases and enzymes.

2431 | TPCA-1 DataSheet

Alternate Name/Synonyms: 2-[(Aminocarbonyl)amino]-5-(4-fluor​ophenyl)-3-thiophenecarboxamide

Appearance: Off-white solid

Formulation: N/A

CAS Number: 507475-17-4

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₂H₁₀FN₃O₂S

Molecular Weight: 279.29

Cell-Permeable?: Yes

Purity: ≥95% by HPLC

Solubilities: DMSO (~25 mg/ml) or EtOH (~3 mg/ml)

Handling: Protect from light and air

Country of Origin: USA

Tag Line: A potent and selective IκB kinase-2 (IKK-2) inhibitor

MDL Number: MFCD09037541

PubChem CID: 9903786

SMILES: C1=CC(=CC=C1C2=CC(=C(S2)NC(=O)N)C(=O)N)F

InChi: InChI=1S/C12H10FN3O2S/c13-7-3-1-6(2-4-7)9-5-8(10(14)17)11(19-9)16-12(15)18/h1-5H,(H2,14,17)(H3,15,16,18)

InChi Key: SAYGKHKXGCPTLX-UHFFFAOYSA-N