TPPU | B3309

TPPU is a potent, brain-permeable, soluble epoxide hydrolase (sEH) inhibitor (IC50 values are 1.1 and 2.1 nM for murine and human receptor, respectively). Inhibits MAPK and NF-κB signaling, as well as reducing ER stress and cell death in models of pancreatitis. The pharmacokinetics of this compound are dramatically superior to those of the 1-adamantylurea based inhibitors, like AUDA.

TPPU is a potent, brain-permeable, soluble epoxide hydrolase (sEH) inhibitor (IC50 values are 1.1 and 2.1 nM for murine and human receptor, respectively). Inhibits MAPK and NF-κB signaling, as well as reducing ER stress and cell death in models of pancreatitis. The pharmacokinetics of this compound are dramatically superior to those of the 1-adamantylurea based inhibitors, like AUDA.

B3309 | TPPU DataSheet

Alternate Name/Synonyms: 1-(4-Trifluoro-methoxy-phenyl)-3-(1-propionylpiperidin-4-yl)urea

Appearance: Crystalline solid

Formulation:

CAS Number: 1222780-33-7

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₆H₂₀F₃N₃O₃

Molecular Weight: 359.34

Cell-Permeable?: FALSE

Purity: ≥98% by HPLC

Solubilities: >30 mg/ml DMSO

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: A potent soluble epoxide hydrolase (sEH) inhibitor

MDL Number:

PubChem CID: 44142782

SMILES: CCC(=O)N1CCC(CC1)NC(=O)NC2=CC=C(C=C2)OC(F)(F)F

InChi: InChI=1S/C16H20F3N3O3/c1-2-14(23)22-9-7-12(8-10-22)21-15(24)20-11-3-5-13(6-4-11)25-16(17,18)19/h3-6,12H,2,7-10H2,1H3,(H2,20,21,24)

InChi Key: AAJMQTLFRTZCJK-UHFFFAOYSA-N