TPX-0005 | B2027

TPX-0005 is a potent ALK inhibitor. It inhibits WT ALK (IC50 1.01 nM) and mutant ALKs including ALK G1202R (IC₅₀ = 1.26 nM) and ALK L1196M (IC₅₀ = 1.08 nM). Moreover, TPX-0005 effectively inhibits tumor growth in vivo in ALK WT and ALK G1202R xenografts. TPX-0005 is also a potent SRC inhibitor (IC₅₀ = 5.3 nM).

TPX-0005 is a potent ALK inhibitor. It inhibits WT ALK (IC50 1.01 nM) and mutant ALKs including ALK G1202R (IC₅₀ = 1.26 nM) and ALK L1196M (IC₅₀ = 1.08 nM). Moreover, TPX-0005 effectively inhibits tumor growth in vivo in ALK WT and ALK G1202R xenografts. TPX-0005 is also a potent SRC inhibitor (IC₅₀ = 5.3 nM).

B2027 | TPX-0005 DataSheet

Alternate Name/Synonyms: (13E,14E,3R,6S)-45-fluoro-3,6-dimethyl-5-oxa-2,8-diaza-1(5,3)-pyrazolo[1,5-a]pyrimidina-4(1,2)-benzenacyclononaphan-9-one

Appearance: Crystalline solid

Formulation: N/A

CAS Number: 2058227-19-1

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₈H₁₈FN₅O₂

Molecular Weight: 355.37

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A potent ALK inhibitor

MDL Number: N/A

PubChem CID: 118265583

SMILES: CC1CNC(=O)C2=CNN3C2=NC(=NC(C4=C(O1)C=CC(=C4)F)C)C=C3

InChi: InChI=1S/C18H18FN5O2/c1-10-8-20-18(25)14-9-21-24-6-5-16(23-17(14)24)22-11(2)13-7-12(19)3-4-15(13)26-10/h3-7,9-11,21H,8H2,1-2H3,(H,20,25)/t10-,11+/m0/s1

InChi Key: RZNJKDGJGCKKNC-WDEREUQCSA-N