Trabectedin | B3084

Trabectedin is a natural product originally isolated from the sea squirt, Ecteinascidia turbinata and is currently prepared synthetically. It interferes with transcription factors, DNA‐binding proteins, DNA repair pathways and shows potent antitumor activity. It suppresses the proliferation of Clear cell sarcoma cell lines with IC₅₀ values ranging from 0.30 nM-0.50 nM. It is approved for the treatment of unresectable or metastatic liposarcoma or leiomyosarcoma who received prior chemotherapy with an anthracycline.

Trabectedin is a natural product originally isolated from the sea squirt, Ecteinascidia turbinata and is currently prepared synthetically. It interferes with transcription factors, DNA‐binding proteins, DNA repair pathways and shows potent antitumor activity. It suppresses the proliferation of Clear cell sarcoma cell lines with IC₅₀ values ranging from 0.30 nM-0.50 nM. It is approved for the treatment of unresectable or metastatic liposarcoma or leiomyosarcoma who received prior chemotherapy with an anthracycline.

B3084 | Trabectedin DataSheet

Alternate Name/Synonyms: Ecteinascidin; [(1R,2R,3R,11S,12S,14R,26R)-5,6',12-trihydroxy-6,7'-dimethoxy-7,21,30-trimethyl-27-oxospiro[17,19,28-trioxa-24-thia-13,30-diazaheptacyclo[12.9.6.13,11.02,13.04,9.015,23.016,20]triaconta-4(9),5,7,15,20,22-hexaene-26,1'-3,4-dihydro-2H-isoquinoline]-22-yl] acetate; ecteinascidin 743; ET-743

Appearance: White to off-white powder

Formulation:

CAS Number: 114899-77-3

Structure Available?: TRUE

Peptide sequence:

Salt Form: FALSE

Molecular Formula: C₃₉H₄₃N₃O₁₁S

Molecular Weight: 761.84

Cell-Permeable?: TRUE

Purity: ≥ 98%

Solubilities: Soluble in DMSO

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: An antitumor agent

MDL Number: MFCD00874849

PubChem CID: 108150

SMILES: CC1=CC2=C(C3C4C5C6=C(C(=C7C(=C6C(N4C(C(C2)N3C)O)COC(=O)C8(CS5)C9=CC(=C(C=C9CCN8)O)OC)OCO7)C)OC(=O)C)C(=C1OC)O

InChi: InChI=1S/C39H43N3O11S/c1-16-9-20-10-22-37(46)42-23-13-50-38(47)39(21-12-25(48-5)24(44)11-19(21)7-8-40-39)14-54-36(30(42)29(41(22)4)26(20)31(45)32(16)49-6)28-27(23)35-34(51-15-52-35)17(2)33(28)53-18(3)43/h9,11-12,22-23,29-30,36-37,40,44-46H,7-8,10,13-15H2,1-6H3/t22-,23-,29+,30+,36+,37-,39+/m0/s1

InChi Key: PKVRCIRHQMSYJX-AIFWHQITSA-N