Traut's Reagent | 2330

KEY FEATURES & APPLICATIONS: • Water-soluble • Adds a 5-atom spacer arm (8.1 Å) to minimize steric hindrance • The spacer is cleavable at the disulfide bond with reducing agent, such as DTT, TCEP, etc. • Commonly used to convert primary amines into sulfhydryl groups in a one-step process is called thiolation • Amine reactive at pH 7-10 and is also an effective thiolation reagent for polysaccharides • Useful RNA-protein crosslinking reagent.

Traut's reagent is a useful reagent for converting primary amine functional groups into free sulfhydryl groups

2330 | Traut's Reagent DataSheet

Alternate Name/Synonyms: 2-Iminothiolane HCl; 2-IT; Dihydro-2-(3H)-thiophenimine hydrochloride; Dihydro-2-(3H)-thiophenimine HCl

Appearance: White solid

Formulation: N/A

CAS Number: 4781-83-3

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₄H₇NS•HCl

Molecular Weight: 137.63

Cell-Permeable?: No

Purity: ≥90% by NMR

Solubilities: H2O or aqueous buffers

Handling: Protect from moisture

Country of Origin: USA

Tag Line: A useful reagent for converting primary amine functional groups into free sulfhydryl groups

MDL Number: MFCD00039013

PubChem CID: 13166855

SMILES: C1CC(=N)SC1.Cl

InChi: InChI=1S/C4H7NS.ClH/c5-4-2-1-3-6-4;/h5H,1-3H2;1H

InChi Key: ATGUDZODTABURZ-UHFFFAOYSA-N