Description
KEY FEATURES & APPLICATIONS: • Water-soluble • Adds a 5-atom spacer arm (8.1 Å) to minimize steric hindrance • The spacer is cleavable at the disulfide bond with reducing agent, such as DTT, TCEP, etc. • Commonly used to convert primary amines into sulfhydryl groups in a one-step process is called thiolation • Amine reactive at pH 7-10 and is also an effective thiolation reagent for polysaccharides • Useful RNA-protein crosslinking reagent.
Traut's reagent is a useful reagent for converting primary amine functional groups into free sulfhydryl groups
2330 | Traut's Reagent DataSheet
Alternate Name/Synonyms: 2-Iminothiolane HCl; 2-IT; Dihydro-2-(3H)-thiophenimine hydrochloride; Dihydro-2-(3H)-thiophenimine HCl
Appearance: White solid
Formulation: N/A
CAS Number: 4781-83-3
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₄H₇NS•HCl
Molecular Weight: 137.63
Cell-Permeable?: No
Purity: ≥90% by NMR
Solubilities: H2O or aqueous buffers
Handling: Protect from moisture
Country of Origin: USA
Tag Line: A useful reagent for converting primary amine functional groups into free sulfhydryl groups
MDL Number: MFCD00039013
PubChem CID: 13166855
SMILES: C1CC(=N)SC1.Cl
InChi: InChI=1S/C4H7NS.ClH/c5-4-2-1-3-6-4;/h5H,1-3H2;1H
InChi Key: ATGUDZODTABURZ-UHFFFAOYSA-N
Additional Information
Storage Condition: |
+4 ̊C |
Shipping Condition: |
Gel Pack |
Shelf Life: |
36 months |