Description
Trifluorothymidine is an inhibitor of TS (thymidylate synthase). It is also a substrate used to study the specificity and kinetics of thymidine kinases. Acts as an anti-herpesvirus drug by blocking viral DNA replication. Decreases CRISPR-mediated HDR (homology-directed repair) efficiency.
Trifluorothymidine is an inhibitor of TS (thymidylate synthase). It is also a substrate used to study the specificity and kinetics of thymidine kinases. Acts as an anti-herpesvirus drug by blocking viral DNA replication. Decreases CRISPR-mediated HDR (homology-directed repair) efficiency.
B1126 | Trifluorothymidine DataSheet
Alternate Name/Synonyms: 2'-Deoxy-5-trifluoromethyluridine; Triflurdine; TFT
Appearance: White Solid
Formulation: N/A
CAS Number: 70-00-8
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₁₀H₁₁F₃N₂O₅
Molecular Weight: 296.2
Cell-Permeable?: Yes
Purity: ≥98% by HPLC
Solubilities: DMSO (>25 mg/ml) of H₂O (>10mg/ml)
Handling: Protect from air and moisture
Country of Origin: USA
Tag Line: A thymidylate synthase inhibitor and HDR blocker
MDL Number: MFCD00006534
PubChem CID: 6256
SMILES: C1C(C(OC1N2C=C(C(=O)NC2=O)C(F)(F)F)CO)O
InChi: InChI=1S/C10H11F3N2O5/c11-10(12,13)4-2-15(9(19)14-8(4)18)7-1-5(17)6(3-16)20-7/h2,5-7,16-17H,1,3H2,(H,14,18,19)/t5-,6+,7+/m0/s1
InChi Key: VSQQQLOSPVPRAZ-RRKCRQDMSA-N
Additional Information
Storage Condition: |
-20°C |
Shipping Condition: |
Gel Pack |
Shelf Life: |
36 months |