Trifluorothymidine | B1126

Trifluorothymidine is an inhibitor of TS (thymidylate synthase). It is also a substrate used to study the specificity and kinetics of thymidine kinases. Acts as an anti-herpesvirus drug by blocking viral DNA replication. Decreases CRISPR-mediated HDR (homology-directed repair) efficiency.

Trifluorothymidine is an inhibitor of TS (thymidylate synthase). It is also a substrate used to study the specificity and kinetics of thymidine kinases. Acts as an anti-herpesvirus drug by blocking viral DNA replication. Decreases CRISPR-mediated HDR (homology-directed repair) efficiency.

B1126 | Trifluorothymidine DataSheet

Alternate Name/Synonyms: 2'-Deoxy-5-trifluoromethyluridine; Triflurdine; TFT

Appearance: White Solid

Formulation: N/A

CAS Number: 70-00-8

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₀H₁₁F₃N₂O₅

Molecular Weight: 296.2

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (>25 mg/ml) of H₂O (>10mg/ml)

Handling: Protect from air and moisture

Country of Origin: USA

Tag Line: A thymidylate synthase inhibitor and HDR blocker

MDL Number: MFCD00006534

PubChem CID: 6256

SMILES: C1C(C(OC1N2C=C(C(=O)NC2=O)C(F)(F)F)CO)O

InChi: InChI=1S/C10H11F3N2O5/c11-10(12,13)4-2-15(9(19)14-8(4)18)7-1-5(17)6(3-16)20-7/h2,5-7,16-17H,1,3H2,(H,14,18,19)/t5-,6+,7+/m0/s1

InChi Key: VSQQQLOSPVPRAZ-RRKCRQDMSA-N