TrkB, Active | 7758

TRKB is a member of the neurotrophic tyrosine receptor kinase (NTRK) family. TRKB is the high affinity catalytic receptor for several "neurotrophins", which are small protein growth factors that induce the survival and differentiation of distinct cell populations (1). TRKB is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway (2). Signalling through TRKB leads to cell differentiation. Mutations in the TRKB gene have been associated with obesity and mood disorders.

7758 | TrkB Active DataSheet

Biomolecule/Target: N/A

Synonyms: TrkB, neurotrophic tyrosine kinase, receptor, type 2

Alternates names: TrkB, neurotrophic tyrosine kinase, receptor, type 2, GP145-TrkB, Neurotrophic tyrosine kinase receptor type 2, TrkB tyrosine kinase, Tropomyosin-related kinase B

Taglines: A high affinity catalytic receptor for several neurotrophins

NCBI Gene ID #: 10850

NCBI Gene Symbol: CCL27

Gene Source: N/A

Accession #: Q9Y4X3

Recombinant: Yes

Source: Baculovirus (Sf9 insect cells)

Purity by SDS-PAGEs: 95%

Assay: SDS-PAGE

Purity: N/A

Assay #2: HPLC

Endotoxin Level: N/A

Activity (Specifications/test method): The specific activity of TRKB was determined to be 74 nmol /min/mg as per activity assay protocol.

Biological activity: N/A

Results: N/A

Binding Capacity: N/A

Unit Definition: N/A

Molecular Weight: 67.0 kDa

Concentration: 5µg/50 µl

Appearance: Liquid

Physical form description: Recombinant protein stored in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 0.25mM DTT, 0.1mM EGTA, 0.1mM EDTA, 0.1mM PMSF, 25% glycerol.

Reconstitution Instructions: N/A

Amino acid sequence: MFLLPPSTAC CTQLYRKPLS DKLLRKVIQV ELQEADGDCH LQAFVLHLAQ RSICIHPQNP SLSQWFEHQE RKLHGTLPKL NFGMLRKMG.