Description
Tryptanthrin is an alkaloid isolated from various plants and shows antimicrobial activity. It inhibits both 5-lipoxygenase and cyclooxygenase-2 with IC₅₀ values of 600 nM and 64 nM, respectively. It suppresses angiogenesis by targeting the VEGFR2-mediated ERK1/2 signalling pathway.
Tryptanthrin is an alkaloid isolated from various plants and shows antimicrobial activity. It inhibits both 5-lipoxygenase and cyclooxygenase-2 with IC₅₀ values of 600 nM and 64 nM, respectively. It suppresses angiogenesis by targeting the VEGFR2-mediated ERK1/2 signalling pathway.
B2951 | Tryptanthrin DataSheet
Alternate Name/Synonyms: indolo[2,1-b]quinazoline-6,12-dione; NSC 349447; Couroupitine a; 11-hydrobenzo[d]quinazolino[3,2-a]azolidine-6,12-dione
Appearance: Solid
Formulation:
CAS Number: 13220-57-0
Structure Available?: True
Peptide sequence:
Salt Form: false
Molecular Formula: C₁₅H₈N₂O₂
Molecular Weight: 248.24
Cell-Permeable?: True
Purity: ≥95%
Solubilities: ~2 mg/ml in DMSO in 0
Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Country of Origin: USA
Tag Line: An inhibitor of 5-lipoxygenase and cyclooxygenase-2
MDL Number:
PubChem CID: 73549
SMILES: C1=CC=C2C(=C1)C(=O)N3C4=CC=CC=C4C(=O)C3=N2
InChi: InChI=1S/C15H8N2O2/c18-13-10-6-2-4-8-12(10)17-14(13)16-11-7-3-1-5-9(11)15(17)19/h1-8H
InChi Key: VQQVWGVXDIPORV-UHFFFAOYSA-N
Additional Information
Storage Condition: |
-20ºC |
Shipping Condition: |
RT |
Shelf Life: |
36 months |