Tryptanthrin | B2951

Tryptanthrin is an alkaloid isolated from various plants and shows antimicrobial activity. It inhibits both 5-lipoxygenase and cyclooxygenase-2 with IC₅₀ values of 600 nM and 64 nM, respectively. It suppresses angiogenesis by targeting the VEGFR2-mediated ERK1/2 signalling pathway.

Tryptanthrin is an alkaloid isolated from various plants and shows antimicrobial activity. It inhibits both 5-lipoxygenase and cyclooxygenase-2 with IC₅₀ values of 600 nM and 64 nM, respectively. It suppresses angiogenesis by targeting the VEGFR2-mediated ERK1/2 signalling pathway.

B2951 | Tryptanthrin DataSheet

Alternate Name/Synonyms: indolo[2,1-b]quinazoline-6,12-dione; NSC 349447; Couroupitine a; 11-hydrobenzo[d]quinazolino[3,2-a]azolidine-6,12-dione

Appearance: Solid

Formulation:

CAS Number: 13220-57-0

Structure Available?: True

Peptide sequence:

Salt Form: false

Molecular Formula: C₁₅H₈N₂O₂

Molecular Weight: 248.24

Cell-Permeable?: True

Purity: ≥95%

Solubilities: ~2 mg/ml in DMSO in 0

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: An inhibitor of 5-lipoxygenase and cyclooxygenase-2

MDL Number:

PubChem CID: 73549

SMILES: C1=CC=C2C(=C1)C(=O)N3C4=CC=CC=C4C(=O)C3=N2

InChi: InChI=1S/C15H8N2O2/c18-13-10-6-2-4-8-12(10)17-14(13)16-11-7-3-1-5-9(11)15(17)19/h1-8H

InChi Key: VQQVWGVXDIPORV-UHFFFAOYSA-N