Tucidinostat | B3059

Tucidinostat is an inhibitor of histone deacetylases (HDACs) with IC₅₀ values of 95 nM, 160 nM, 67 nM and 78 nM for HDAC1, HDAC2, HDAC3 and HDAC10 respectively. It shows potent antitumor activity. It inhibits several human derived tumor cell lines, such as HL-60, U2OS, LNCaP with GI₅₀ values of 0.4-40 μM but has no effect on the growth of non-cancerous CCC-HEK human fetal kidney or CCC-HEL human liver cells. It (12.5-50 mg/kg, p.o) reduces tumor growth in mouse xenograft models.

Tucidinostat is an inhibitor of histone deacetylases (HDACs) with IC₅₀ values of 95 nM, 160 nM, 67 nM and 78 nM for HDAC1, HDAC2, HDAC3 and HDAC10 respectively. It shows potent antitumor activity. It inhibits several human derived tumor cell lines, such as HL-60, U2OS, LNCaP with GI₅₀ values of 0.4-40 μM but has no effect on the growth of non-cancerous CCC-HEK human fetal kidney or CCC-HEL human liver cells. It (12.5-50 mg/kg, p.o) reduces tumor growth in mouse xenograft models.

B3059 | Tucidinostat DataSheet

Alternate Name/Synonyms: Chidamide; Epidaza; N-(2-amino-4-fluorophenyl)-4-[[[(E)-3-pyridin-3-ylprop-2-enoyl]amino]methyl]benzamide; (E)-N-(2-amino-4-fluorophenyl)-4-((3-(pyridin-3-yl)acrylamido)methyl)benzamide; N-(2-Amino-4-fluorophenyl)-4-(((1-oxo-3-(3-pyridinyl)-2-propen-1-yl)amino)methyl)benzamide; CS-055; HBI-8000

Appearance: Off white Solid

Formulation:

CAS Number: 1616493-44-7

Structure Available?: TRUE

Peptide sequence:

Salt Form: FALSE

Molecular Formula: C₂₂H₁₉FN₄O₂

Molecular Weight: 390.41

Cell-Permeable?: TRUE

Purity: ≥98%

Solubilities: ~20 mg/ml in DMSO and DMF

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: An inhibitor of histone deacetylases

MDL Number: MFCD28100259

PubChem CID: 12136798

SMILES: C1=CC(=CN=C1)C=CC(=O)NCC2=CC=C(C=C2)C(=O)NC3=C(C=C(C=C3)F)N

InChi: InChI=1S/C22H19FN4O2/c23-18-8-9-20(19(24)12-18)27-22(29)17-6-3-16(4-7-17)14-26-21(28)10-5-15-2-1-11-25-13-15/h1-13H,14,24H2,(H,26,28)(H,27,29)/b10-5+

InChi Key: SZMJVTADHFNAIS-BJMVGYQFSA-N