TVB-2640 | B3125

TVB-2640 is an oral, selective fatty acid synthase (FASN) inhibitor. It reduces hepatic de novo lipogenesis in males with metabolic abnormalities. It is being evaluated in phase 2 clinical trials to treat KRAS mutant non-small cell lung carcinomas.

TVB-2640 is an oral, selective fatty acid synthase (FASN) inhibitor. It reduces hepatic de novo lipogenesis in males with metabolic abnormalities. It is being evaluated in phase 2 clinical trials to treat KRAS mutant non-small cell lung carcinomas.

B3125 | TVB-2640 DataSheet

Alternate Name/Synonyms: Fasn-IN-2; 4-[1-[4-cyclobutyl-2-methyl-5-(5-methyl-1H-1,2,4-triazol-3-yl)benzoyl]piperidin-4-yl]benzonitrile

Appearance: Off-white to white solid powder

Formulation:

CAS Number: 1399177-37-7

Structure Available?: TRUE

Peptide sequence:

Salt Form: FALSE

Molecular Formula: C₂₇H₂₉N₅O

Molecular Weight: 439.55

Cell-Permeable?: TRUE

Purity: ≥ 98%

Solubilities: ~80 mg/ml in DMSO or Ethanol

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: An oral, selective fatty acid synthase (FASN) inhibitor

MDL Number:

PubChem CID: 66548316

SMILES: CC1=CC(=C(C=C1C(=O)N2CCC(CC2)C3=CC=C(C=C3)C#N)C4=NNC(=N4)C)C5CCC5

InChi: InChI=1S/C27H29N5O/c1-17-14-24(22-4-3-5-22)25(26-29-18(2)30-31-26)15-23(17)27(33)32-12-10-21(11-13-32)20-8-6-19(16-28)7-9-20/h6-9,14-15,21-22H,3-5,10-13H2,1-2H3,(H,29,30,31)

InChi Key: BBGOSBDSLYHMRA-UHFFFAOYSA-N