Description
TY-52156 is a novel S1P3 receptor antagonist (Ki = 110 nM). It preferentially inhibits the S1P-induced increase in intracellular calcium in Chinese hamster ovary cells expressing S1P3 over cell expressing S1P1, S1P2, or S1P4. TY-52156 has been shown to suppress FTY720-induced S1P3receptor-mediated coronary flow in isolated perfused rat hearts. TY-52156 can also inhibit S1P-induced breast cancer stem cell expansion in vitro.
TY-52156 is a novel S1P3 receptor antagonist (Ki = 110 nM). It preferentially inhibits the S1P-induced increase in intracellular calcium in Chinese hamster ovary cells expressing S1P3 over cell expressing S1P1, S1P2, or S1P4. TY-52156 has been shown to suppress FTY720-induced S1P3receptor-mediated coronary flow in isolated perfused rat hearts. TY-52156 can also inhibit S1P-induced breast cancer stem cell expansion in vitro.
Alternate Name/Synonyms: N-(4-Chlorophenyl)-3,3-dimethyl
Appearance: Yellow solid
Formulation: N/A
CAS Number: 934369-14-9
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: N/A
Molecular Formula: C₁₈H₁₉Cl₂N₃O
Molecular Weight: 364.27
Cell-Permeable?: Yes
Purity: ≥98% by HPLC
Solubilities: DMSO (>35 mg/ml) or EtOH (>30 mg/ml)
Handling: Protect from air and light
Country of Origin: USA
Tag Line: A novel S1P3 receptor antagonist
MDL Number: N/A
PubChem CID: 16046248
SMILES: CC(C)(C)C(=O)C(=NC1=CC=C(C=C1)Cl)NNC2=CC=C(C=C2)Cl
InChi: InChI=1S/C18H19Cl2N3O/c1-18(2,3)16(24)17(21-14-8-4-12(19)5-9-14)23-22-15-10-6-13(20)7-11-15/h4-11,22H,1-3H3,(H,21,23)
InChi Key: XONRRGIRSGNWFP-UHFFFAOYSA-N
Additional Information
Storage Condition: |
-20°C |
Shipping Condition: |
Gel Pack |
Shelf Life: |
36 months |