TY-52156 | B1582

TY-52156 is a novel S1P3 receptor antagonist (Ki = 110 nM). It preferentially inhibits the S1P-induced increase in intracellular calcium in Chinese hamster ovary cells expressing S1P3 over cell expressing S1P1, S1P2, or S1P4. TY-52156 has been shown to suppress FTY720-induced S1P3receptor-mediated coronary flow in isolated perfused rat hearts. TY-52156 can also inhibit S1P-induced breast cancer stem cell expansion in vitro.

TY-52156 is a novel S1P3 receptor antagonist (Ki = 110 nM). It preferentially inhibits the S1P-induced increase in intracellular calcium in Chinese hamster ovary cells expressing S1P3 over cell expressing S1P1, S1P2, or S1P4. TY-52156 has been shown to suppress FTY720-induced S1P3receptor-mediated coronary flow in isolated perfused rat hearts. TY-52156 can also inhibit S1P-induced breast cancer stem cell expansion in vitro.

B1582 | TY-52156 DataSheet

Alternate Name/Synonyms: N-(4-Chlorophenyl)-3,3-dimethyl

Appearance: Yellow solid

Formulation: N/A

CAS Number: 934369-14-9

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: N/A

Molecular Formula: C₁₈H₁₉Cl₂N₃O

Molecular Weight: 364.27

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (>35 mg/ml) or EtOH (>30 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A novel S1P3 receptor antagonist

MDL Number: N/A

PubChem CID: 16046248

SMILES: CC(C)(C)C(=O)C(=NC1=CC=C(C=C1)Cl)NNC2=CC=C(C=C2)Cl

InChi: InChI=1S/C18H19Cl2N3O/c1-18(2,3)16(24)17(21-14-8-4-12(19)5-9-14)23-22-15-10-6-13(20)7-11-15/h4-11,22H,1-3H3,(H,21,23)

InChi Key: XONRRGIRSGNWFP-UHFFFAOYSA-N