U-18666A | 9469

U-18666A is a cell-permeable cholesterol trafficking inhibitor. It inhibits cholesterol transport from late endosomes/lysosomes to the endoplasmic reticulum (ER), but not cholesterol transport to the plasma membrane as demonstrated in many cell types including macrophages, primary cortical neurons and primary fibroblasts.

U-18666A is a cell-permeable cholesterol trafficking inhibitor. It inhibits cholesterol transport from late endosomes/lysosomes to the endoplasmic reticulum (ER), but not cholesterol transport to the plasma membrane as demonstrated in many cell types including macrophages, primary cortical neurons and primary fibroblasts.

9469 | U-18666A DataSheet

Alternate Name/Synonyms: (3β)-3-[2-(Diethylamino)ethoxy]androst-5-en-17-one hydrochloride

Appearance: White solid

Formulation: N/A

CAS Number: 3039-71-2

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: N/A

Molecular Formula: C₂₅H₄₁F₂NO₂.HCl

Molecular Weight: 424.07

Cell-Permeable?: Yes

Purity: ≥95%

Solubilities: H₂O (>30 mg/ml)

Handling: Protect from air and moisture

Country of Origin: USA

Tag Line: A cell-permeable cholesterol trafficking inhibitor.

MDL Number: MFCD00210908

PubChem CID: 9954082

SMILES: CCN(CC)CCOC1CCC2(C3CCC4(C(C3CC=C2C1)CCC4=O)C)C.Cl

InChi: nChI=1S/C25H41NO2.ClH/c1-5-26(6-2)15-16-28-19-11-13-24(3)18(17-19)7-8-20-21-9-10-23(27)25(21,4)14-12-22(20)24;/h7,19-22H,5-6,8-17H2,1-4H3;1H/t19-,20-,21-,22-,24-,25-;/m0./s1

InChi Key: GZFYZYBWLCYBMI-MYZJJQSMSA-N