Description
UF 010 is class I HDAC inhibitor that displays >6- fold selectivity over other HDACs. It has an IC₅₀ value of 0.06, 0.1, and 1.5 μM for HDACs 3, 2, 1 and 8 respectively. In vitro experimental data shows accumulation of acetylated histones in HCT116 cells. UF 010 is known to arrest cells at G1/S transition inhibiting proliferation of various cancer cell lines.
UF 010 is class I HDAC inhibitor that displays >6- fold selectivity over other HDACs. It has an IC₅₀ value of 0.06, 0.1, and 1.5 μM for HDACs 3, 2, 1 and 8 respectively. In vitro experimental data shows accumulation of acetylated histones in HCT116 cells. UF 010 is known to arrest cells at G1/S transition inhibiting proliferation of various cancer cell lines.
Alternate Name/Synonyms: 4-Bromo-N'-butylbenzohydrazide
Appearance: White Solid
Formulation: N/A
CAS Number: 537672-41-6
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₁₁H₁₅BrN₂O
Molecular Weight: 271.15
Cell-Permeable?: Yes
Purity: ≥98% by HPLC
Solubilities: DMSO(>25 mg/ml)
Handling: Protect from air and light
Country of Origin: USA
Tag Line: UF 010 is potent and selective class I HDAC inhibitor
MDL Number:
PubChem CID: 4596836
SMILES: CCCCNNC(=O)C1=CC=C(C=C1)Br
InChi: 1S/C11H15BrN2O/c1-2-3-8-13-14-11(15)9-4-6-10(12)7-5-9/h4-7,13H,2-3,8H2,1H3,(H,14,15)
InChi Key: BVQCFCYPFJOOAV-UHFFFAOYSA-N
Additional Information
Storage Condition: |
-20°C |
Shipping Condition: |
Gel Pack |
Shelf Life: |
36 months |