UNBS-5162 | B2587

UNBS5162 is a novel naphthalimide that suppresses the expression of CXCL chemokines. In vitro exposure of PC-3 prostate cancer cells to 1 µM UNBS5162 for five successive days is shown to decrease the expression of proangiogenic CXCL chemokines. UNBS5162 also displays antiangiogenic properties in vivo in an orthotopic PC-3 model.

UNBS5162 is a novel naphthalimide that suppresses the expression of CXCL chemokines. In vitro exposure of PC-3 prostate cancer cells to 1 µM UNBS5162 for five successive days is shown to decrease the expression of proangiogenic CXCL chemokines. UNBS5162 also displays antiangiogenic properties in vivo in an orthotopic PC-3 model.

B2587 | UNBS-5162 DataSheet

Alternate Name/Synonyms: UNBS 5162, 1-(2-(2-(dimethylamino)ethyl)-1,3-dioxo-2,3-dihydro-1H-benzo[de]isoquinolin-5-yl)urea, UNBS5162

Appearance: Yellow solid

Formulation:

CAS Number: 956590-23-1

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₇H₁₈N₄O₃

Molecular Weight: 326.35

Cell-Permeable?: True

Purity: ≥98% by HPLC

Solubilities: in DMSO

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: A CXCL chemokines receptor antagonist

MDL Number:

PubChem CID: 16048966

SMILES: O=C(C1=CC(NC(N)=O)=CC2=C1C3=CC=C2)N(CCN(C)C)C3=O

InChi: InChI=1S/C17H18N4O3/c1-20(2)6-7-21-15(22)12-5-3-4-10-8-11(19-17(18)24)9-13(14(10)12)16(21)23/h3-5,8-9H,6-7H2,1-2H3,(H3,18,19,24)

InChi Key: