Description
UNBS5162 is a novel naphthalimide that suppresses the expression of CXCL chemokines. In vitro exposure of PC-3 prostate cancer cells to 1 µM UNBS5162 for five successive days is shown to decrease the expression of proangiogenic CXCL chemokines. UNBS5162 also displays antiangiogenic properties in vivo in an orthotopic PC-3 model.
UNBS5162 is a novel naphthalimide that suppresses the expression of CXCL chemokines. In vitro exposure of PC-3 prostate cancer cells to 1 µM UNBS5162 for five successive days is shown to decrease the expression of proangiogenic CXCL chemokines. UNBS5162 also displays antiangiogenic properties in vivo in an orthotopic PC-3 model.
Alternate Name/Synonyms: UNBS 5162, 1-(2-(2-(dimethylamino)ethyl)-1,3-dioxo-2,3-dihydro-1H-benzo[de]isoquinolin-5-yl)urea, UNBS5162
Appearance: Yellow solid
Formulation:
CAS Number: 956590-23-1
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₁₇H₁₈N₄O₃
Molecular Weight: 326.35
Cell-Permeable?: True
Purity: ≥98% by HPLC
Solubilities: in DMSO
Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Country of Origin: USA
Tag Line: A CXCL chemokines receptor antagonist
MDL Number:
PubChem CID: 16048966
SMILES: O=C(C1=CC(NC(N)=O)=CC2=C1C3=CC=C2)N(CCN(C)C)C3=O
InChi: InChI=1S/C17H18N4O3/c1-20(2)6-7-21-15(22)12-5-3-4-10-8-11(19-17(18)24)9-13(14(10)12)16(21)23/h3-5,8-9H,6-7H2,1-2H3,(H3,18,19,24)
InChi Key:
Additional Information
Storage Condition: |
-20ºC |
Shipping Condition: |
Gel Pack |
Shelf Life: |
36 months |