UNC-2025 | B1262

UNC-2025 is a potent inhibitor of the tyrosine kinases Mer and Flt3 (IC₅₀s = 0.74 and 0.80 nM, respectively). It less potently inhibits Axl and Tyro3 (IC₅₀s = 14 and 17 nM, respectively) and a panel of related kinases. UNC2025 blocks colony formation of Mer- and Flt3-dependent tumor cell lines and inhibits Mer phosphorylation in bone marrow leukemia cells in vivo.

UNC-2025 is a potent inhibitor of the tyrosine kinases Mer and Flt3 (IC₅₀s = 0.74 and 0.80 nM, respectively). It less potently inhibits Axl and Tyro3 (IC₅₀s = 14 and 17 nM, respectively) and a panel of related kinases. UNC2025 blocks colony formation of Mer- and Flt3-dependent tumor cell lines and inhibits Mer phosphorylation in bone marrow leukemia cells in vivo.

B1262 | UNC-2025 DataSheet

Alternate Name/Synonyms: (1R,4R)-4-(2-(butylamino)-5-(4-((4-methylpiperazin-1-yl)methyl)phenyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)cyclohexanol; MRX-6313

Appearance: Crystaline solid

Formulation: N/A

CAS Number: 1429881-91-3

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: N/A

Molecular Formula: C₂₈H₄₀N₆O

Molecular Weight: 476.66

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (>10 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A potent inhibitor of the tyrosine kinases Mer and Flt3

MDL Number: N/A

PubChem CID: 73425588

SMILES: CCCCNC1=NC=C2C(=CN(C2=N1)C3CCC(CC3)O)C4=CC=C(C=C4)CN5CCN(CC5)C

InChi: InChI=1S/C28H40N6O/c1-3-4-13-29-28-30-18-25-26(20-34(27(25)31-28)23-9-11-24(35)12-10-23)22-7-5-21(6-8-22)19-33-16-14-32(2)15-17-33/h5-8,18,20,23-24,35H,3-4,9-17,19H2,1-2H3,(H,29,30,31)

InChi Key: MJSHVHLADKXCML-UHFFFAOYSA-N