UNC0631 | 2605

UNC0631 is a potent and selective inhibitor of G9a activity in vitro (IC₅₀ = 4 nM) and G9a/GLP-mediated dimethylation of histone 3 on lysine 9 in MDA-MB-231 cells (IC₅₀ = 25 nM). It potently inhibits G9a/GLP activity in a variety of cancer cell lines as well as in the human fetal lung IMR-90 cell line. Also displays excellent separation of functional potency versus cell toxicity.

UNC0631 is a potent and selective inhibitor of G9a activity in vitro (IC₅₀ = 4 nM) and G9a/GLP-mediated dimethylation of histone 3 on lysine 9 in MDA-MB-231 cells (IC₅₀ = 25 nM). It potently inhibits G9a/GLP activity in a variety of cancer cell lines as well as in the human fetal lung IMR-90 cell line.

2605 | UNC0631 DataSheet

Alternate Name/Synonyms: [N-(1-(cyclohexylmethyl)piperidin-4-yl)-2-(4-isopropyl-1,4-diazepan-1-yl)-6-methoxy-7-(3-(piperidin-1-yl)propoxy)quinazolin-4-amine

Appearance: White to off-white solid

Formulation: N/A

CAS Number: 1320288-19-4

Structure Available?: Y

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₃₇H₆₁N₇O₂

Molecular Weight: 635.93

Cell-Permeable?: Yes

Purity: >98% by HPLC

Solubilities: DMSO (~30 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A potent G9a inhibitor

MDL Number: N/A

PubChem CID: N/A

SMILES: CC(C)N(CC1)CCCN1C2=NC(C=C(OCCCN(C)CC)C(OC)=C3)=C3C(NC(CC4)CCN4CC5CCCCC5)=N2

InChi: InChI=1S/C35H59N7O2/c1-6-39(4)16-11-23-44-33-25-31-30(24-32(33)43-5)34(38-35(37-31)42-18-10-17-41(21-22-42)27(2)3)36-29-14-19-40(20-15-29)26-28-12-8-7-9-13-28/h24-25,27-29H,6-23,26H2,1-5H3,(H,36,37,38)

InChi Key: GJFNQXAYZZYAQU-UHFFFAOYSA-N