UNC0646 | 2606

UNC0646 is a potent and selective inhibitor of protein lysine methyltransferases G9a and GLP activities in vitro (IC₅₀s = 6 and 15 nM, respectively) ; inhibits G9a/GLP-mediated dimethylation of histone 3 on lysine 9 in MDA-MB-231 cells (IC₅₀ = 26 nM). It is highly selective for G9a/GLP over several other protein lysine and arginine methyltransferases.UNC0646 potently inhibits G9a/GLP activity in a variety of cancer cell lines as well as in the human fetal lung IMR-90 line.

UNC0646 is a potent and selective inhibitor of protein lysine methyltransferases G9a and GLP activities in vitro (IC₅₀s = 6 and 15 nM, respectively) ; inhibits G9a/GLP-mediated dimethylation of histone 3 on lysine 9 in MDA-MB-231 cells (IC₅₀ = 26 nM). It is highly selective for G9a/GLP over several other protein lysine and arginine methyltransferases.

2606 | UNC0646 DataSheet

Alternate Name/Synonyms: N-​(1-​cyclohexyl-​4-​piperidinyl)-​2-​[hexahydro-​4-​(1-​methylethyl)-​1H-​1,​4-​diazepin-​1-​yl]-​6-​methoxy-​7-​[3-​(1-​piperidinyl)propoxy]-​4-​quinazolinamine

Appearance: Pale yellow solid

Formulation: N/A

CAS Number: 1320288-17-2

Structure Available?: Y

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₃₆H₅₉N₇O₂

Molecular Weight: 621.9

Cell-Permeable?: Yes

Purity: >98% by HPLC

Solubilities: DMSO (~50 mg/ml) or EtOH (~50 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A potent G9a inhibitor

MDL Number: N/A

PubChem CID: 53315882

SMILES: CC(C)N1CCCN(CC1)C2=NC3=CC(=C(C=C3C(=N2)NC4CCN(CC4)C5CCCCC5)OC)OCCCN6CCCCC6

InChi: InChI=1S/C36H59N7O2/c1-28(2)41-19-10-20-43(24-23-41)36-38-32-27-34(45-25-11-18-40-16-8-5-9-17-40)33(44-3)26-31(32)35(39-36)37-29-14-21-42(22-15-29)30-12-6-4-7-13-30/h26-30H,4-25H2,1-3H3,(H,37,38,39)

InChi Key: OUKWLRHRXOPODD-UHFFFAOYSA-N