Description
URMC-099 is a brain-permeable, mixed lineage kinase (MLK) inhibitor with IC₅₀ values of 19 nM, 42 nM, 14 nM, and 150 nM, for MLK1, MLK2, MLK3, and DLK, respectively. In vitro, URMC-099 treatment reduces inflammatory cytokine production by HIV-1 Tat-exposed microglia and prevents destruction and phagocytosis of cultured neuronal axons by these cells.
URMC-099 is a brain-permeable, mixed lineage kinase (MLK) inhibitor with IC₅₀ values of 19 nM, 42 nM, 14 nM, and 150 nM, for MLK1, MLK2, MLK3, and DLK, respectively. In vitro, URMC-099 treatment reduces inflammatory cytokine production by HIV-1 Tat-exposed microglia and prevents destruction and phagocytosis of cultured neuronal axons by these cells.
Alternate Name/Synonyms: 3-(1H-indol-5-yl)-5-(4-((4-methylpiperazin-1-yl)methyl)phenyl)-1H-pyrrolo[2,3-b]pyridine
Appearance: Crystalline solid
Formulation: N/A
CAS Number: 1229582-33-5
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: N/A
Molecular Formula: C₂₇H₂₇N₅
Molecular Weight: 421.55
Cell-Permeable?: Yes
Purity: ≥98% by HPLC
Solubilities: DMSO (~5 mg/ml)
Handling: Protect from air and light
Country of Origin: USA
Tag Line: A mixed lineage kinase (MLK) inhibitor
MDL Number: N/A
PubChem CID: 54764565
SMILES: CN1CCN(CC1)CC2=CC=C(C=C2)C3=CN=C4C(=C3)C(=CN4)C5=CC6=C(C=C5)NC=C6
InChi: InChI=1S/C27H27N5/c1-31-10-12-32(13-11-31)18-19-2-4-20(5-3-19)23-15-24-25(17-30-27(24)29-16-23)21-6-7-26-22(14-21)8-9-28-26/h2-9,14-17,28H,10-13,18H2,1H3,(H,29,30)
InChi Key: QKKIWEILHCXECO-UHFFFAOYSA-N
Additional Information
Storage Condition: |
-20°C |
Shipping Condition: |
Gel Pack |
Shelf Life: |
36 months |