USP7/USP47 Inhibitor | B2538

USP7/USP47 inhibitor is a dual inhibitor of ubiquitin-specific protease 7 (USP7) and USP47 (IC₅₀s = 0.42 and 1 μM, respectively). It is selective for USP7 and USP47 over USP2, USP5, USP8, USP21, USP28, caspase-3, and cathepsin B (IC₅₀s = >31.6 μM).

USP7/USP47 inhibitor is a dual inhibitor of ubiquitin-specific protease 7 (USP7) and USP47 (IC₅₀s = 0.42 and 1 μM, respectively). It is selective for USP7 and USP47 over USP2, USP5, USP8, USP21, USP28, caspase-3, and cathepsin B (IC₅₀s = >31.6 μM).

B2538 | USP7/USP47 Inhibitor DataSheet

Alternate Name/Synonyms: 4-cyano-5-[(3,5-dichloro-4-pyridinyl)thio]-N-[4-(methylsulfonyl)phenyl]-2-thiophenecarboxamide

Appearance: Crystalline solid

Formulation:

CAS Number: 1247825-37-1

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₈H₁₁Cl₂N₃O₃S₃

Molecular Weight: 484.4

Cell-Permeable?: True

Purity: ≥ 98% by HPLC

Solubilities: >40 mg/ml in DMSO

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: USP7-USP47 inhibitor is a dual inhibitor of ubiquitin-specific protease 7 (USP7) and USP47

MDL Number:

PubChem CID: 51031028

SMILES: CS(C1=CC=C(NC(C2=CC(C#N)=C(SC3=C(Cl)C=NC=C3Cl)S2)=O)C=C1)(=O)=O

InChi: InChI=1S/C18H11Cl2N3O3S3/c1-29(25,26)12-4-2-11(3-5-12)23-17(24)15-6-10(7-21)18(27-15)28-16-13(19)8-22-9-14(16)20/h2-6,8-9H,1H3,(H,23,24)

InChi Key: GUDJFFQZIISQJB-UHFFFAOYSA-N