USP7/USP47 Inhibitor, P 22077 | 2301

A cell-permeable inhibitor of the ubiquitin-specific protease (IC₅₀ = 8.6 µM) and the closely related deubiquitinase (DUB) USP47. P22077 displays weak or no inhibition (EC₅₀>50 µM) towards a panel of 14 isopeptidases and other proteases. Inhibits USP7-mediated p53 deubiquitination.

P 22077 is a cell-permeable inhibitor of the ubiquitin-specific protease (IC₅₀ = 8.6 µM) and the closely related deubiquitinase (DUB) USP47.

2301 | USP7/USP47 Inhibitor, P 22077 DataSheet

Alternate Name/Synonyms: 1-(5-(2,4-Difluorophenylthio)-4-nitrothiophen-2-yl)ethanone; DUB inhibitor

Appearance: Yellow solid

Formulation: N/A

CAS Number: 1247819-59-5

Structure Available?: Yes

Peptide sequence: No

Salt Form: No

Molecular Formula: C₁₂H₇F₂NO₃S₂

Molecular Weight: 315.32

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (~ 30 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A USP7/USP47 inhibitor

MDL Number: N/A

PubChem CID: N/A

SMILES: FC1=CC(F)=CC=C1SC2=C([N+]([O-])=O)C=C(C(C)=O)S2

InChi: InChI=1S/C12H7F2NO3S2/c1-6(16)11-5-9(15(17)18)12(20-11)19-10-3-2-7(13)4-8(10)14/h2-5H,1H3

InChi Key: RMAMGGNACJHXHO-UHFFFAOYSA-N