Validamycin A | B1540

Validamycin A is an antifungal agent used to protect rice plants against sheath blight caused by the pathogenic fungus, R. solani, due to its ability to inhibit trehalase, a trehalose-hydrolizing enzyme (Ki = 1.9 nM; IC50 = 0.7 μM). It is also effective against the growth and sporulation of R. cerealis, F. culmorum, and other fungi. Validamycin A also demonstrates antiviral activity against fungal plant pathogens, including Pellicularia sasakii and Rhizoctonia solani, but does not appear to be fungicidal in these cases.

Validamycin A is an antifungal agent used to protect rice plants against sheath blight caused by the pathogenic fungus, R. solani, due to its ability to inhibit trehalase, a trehalose-hydrolizing enzyme (Ki = 1.9 nM; IC50 = 0.7 μM). It is also effective against the growth and sporulation of R. cerealis, F. culmorum, and other fungi. Validamycin A also demonstrates antiviral activity against fungal plant pathogens, including Pellicularia sasakii and Rhizoctonia solani, but does not appear to be fungicidal in these cases.

B1540 | Validamycin A DataSheet

Alternate Name/Synonyms: 1,5,6-trideoxy-4-O-β-D-glucopyranosyl-5-(hydroxymethyl)-1-[[(1S,4R,5S,6S)-4,5,6-trihydroxy-3-(hydroxymethyl)-2-cyclohexen-1-yl]amino]-D-chiro-inositol; Validamycin; Validacin; Valimon

Appearance: White to off-white solid

Formulation: N/A

CAS Number: 37248-47-8

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: N/A

Molecular Formula: C₂₀H₃₅NO₁₃

Molecular Weight: 497.49

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (2 mg/ml)

Handling: Protect from air and moisture

Country of Origin: USA

Tag Line: An antifungal agent

MDL Number: MFCD09028089

PubChem CID: 443629

SMILES: C1C(C(C(C(C1NC2C=C(C(C(C2O)O)O)CO)O)O)OC3C(C(C(C(O3)CO)O)O)O)CO

InChi: InChI=1S/C20H35NO13/c22-3-6-1-8(12(26)15(29)11(6)25)21-9-2-7(4-23)19(17(31)13(9)27)34-20-18(32)16(30)14(28)10(5-24)33-20/h1,7-32H,2-5H2/t7-,8+,9+,10-,11-,12+,13+,14-,15+,16+,17-,18-,19-,20+/m1/s1

InChi Key: JARYYMUOCXVXNK-CSLFJTBJSA-N