400

Vatalanib Dihydrochloride, 50 mg

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SKU:
400-SIH-484-50MG-GEN
Availability:
IN STOCK
$1,967.00

Description

Vatalanib Dihydrochloride, 50 mg

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Additional Information

Short Description:
VEGFR inhibitor
Research Area:
Cell Signaling, Cancer, Apoptosis, Cardiovascular System, Cancer Growth Inhibitors, Growth Factor Receptor Inhibitors
Alternative Name(s):
N-(4-Chlorophenyl)-4-(4-pyridinylmethyl)-1-phthalazinamine dihydrochloride
Category:
Small Molecules
Product Type:
Inhibitor
CAS No.:
212141-51-0
Molecular Formula:
C20H17Cl3N4
Molecular Weight:
419,7
Source:
Synthetic
Purity:
≥96%
Solubility:
Soluble in DMSO (30 mg/ml), ethanol (10 mg/ml) with warming; very poorly soluble in water; maximum solubility in plain water is estimated to be about 10-20 µM; buffers, serum, or other additives may increase or decrease the aqueous solubility.Also so
Appearance:
Solid
Storage:
-20ºC
Shipping:
Shipped Ambient
SMILES:
C1=CC=C2C(=C1)C(=NN=C2NC3=CC=C(C=C3)Cl)CC4=CC=NC=C4.Cl.Cl
InChI:
InChI=1S/C20H15ClN4.2ClH/c21-15-5-7-16(8-6-15)23-20-18-4-2-1-3-17(18)19(24-25-20)13-14-9-11-22-12-10-14;;/h1-12H,13H2,(H,23,25);2*1H
InChIKey:
AZUQEHCMDUSRLH-UHFFFAOYSA-N
Field of Use:
For in vitro research use only.
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Cell-permeable. An inhibitor of the VEGFR tyrosine kinases VEGFR-1 (Flt-1, IC₅₀ = 77 nM) and VEGFR-2 (FLK-1/KDR, IC₅₀ = 37 nM), with slightly higher potency against the latter. At higher...
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