Vatalanib, Free Base | 2026

Cell-permeable. An inhibitor of the VEGFR tyrosine kinases VEGFR-1 (Flt-1, IC₅₀ = 77 nM) and VEGFR-2 (FLK-1/KDR, IC₅₀ = 37 nM), with slightly higher potency against the latter. At higher concentrations, other tyrosine kinases are also inhibited, including PDGFR-β (IC₅₀ = 580 nM), c-KIT (IC₅₀ = 730 nM), FLT-4 (IC₅₀ = 660 nM) and c-FMS (IC₅₀ = 1.4 µM). On the other hand, vatalanib is not active against the EGFR, c-SRC, v-ABL, and protein kinase Cα (IC₅₀ > 10 µM).

Vatalanib, Free Base is an inhibitor of the VEGFR tyrosine kinases VEGFR-1 (Flt-1, IC₅₀ = 77 nM) and VEGFR-2 (FLK-1/KDR, IC₅₀ = 37 nM), with slightly higher potency against the latter. At higher concentrations, other tyrosine kinases are also inhibited, including PDGFR-β (IC₅₀ = 580 nM), c-KIT (IC₅₀ = 730 nM), FLT-4 (IC₅₀ = 660 nM) and c-FMS (IC₅₀ = 1.4 µM). On the other hand, vatalanib is not active against the EGFR, c-SRC, v-ABL, and protein kinase Cα (IC₅₀ > 10 µM).

2026 | Vatalanib, Free Base DataSheet

Alternate Name/Synonyms: CGP-79787; PTK 787; ZK222584

Appearance: Off-white solid

Formulation: N/A

CAS Number: 212141-54-3

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₀H₁₅ClN₄

Molecular Weight: 346.81

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (25 mg/ml) or EtOH (~ 6 mg/ml)

Handling: Protect from air and moisture

Country of Origin: USA

Tag Line: A potent inhibitor of the VEGFR tyrosine kinases

MDL Number: MFCD08458963

PubChem CID: 151194

SMILES: C1=CC=C2C(=C1)C(=NN=C2NC3=CC=C(C=C3)Cl)CC4=CC=NC=C4

InChi: InChI=1S/C20H15ClN4/c21-15-5-7-16(8-6-15)23-20-18-4-2-1-3-17(18)19(24- 25-20)13-14-9-11-22-12-10-14/h1-12H,13H2,(H,23,25)

InChi Key: YCOYDOIWSSHVCK-UHFFFAOYSA-N