VEGFR-2 inhibitor | B2938

VEGFR-2 inhibitor is a potent inhibitor of Vascular Endothelial Growth Factor-2 Receptor Tyrosine Kinase (VEGFR-2). It shows 79% inhibition in the murine matrigel model for vascular permeability at 100 mg/kg. It shows an ED₅₀ of 16.3 mg/kg in the rat corneal angiogenesis model.

VEGFR-2 inhibitor is a potent inhibitor of Vascular Endothelial Growth Factor-2 Receptor Tyrosine Kinase (VEGFR-2). It shows 79% inhibition in the murine matrigel model for vascular permeability at 100 mg/kg. It shows an ED₅₀ of 16.3 mg/kg in the rat corneal angiogenesis model.

B2938 | VEGFR-2 inhibitor DataSheet

Alternate Name/Synonyms: 4-((2-((4-Chloro-3-((((2S)-1-methyl-2-pyrrolidinyl)methyl)oxy)-phenyl)amino)-1,3-benzoxazol-5-yl)oxy)-N-methyl-2-pyridinecarboxamide

Appearance: Solid

Formulation:

CAS Number: 769960-39-6

Structure Available?: True

Peptide sequence:

Salt Form: false

Molecular Formula: C₂₆H₂₆ClN₅O₄

Molecular Weight: 507.97

Cell-Permeable?: True

Purity: 95%

Solubilities: Soluble in in DMSO

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: An inhibitor of VEGFR-2

MDL Number:

PubChem CID:

SMILES: O=C(C1=NC=CC(OC2=CC=C(OC(NC3=CC=C(Cl)C(OC[C@H]4N(C)CCC4)=C3)=N5)C5=C2)=C1)NC

InChi: InChI=1S/C26H26ClN5O4/c1-28-25(33)22-14-19(9-10-29-22)35-18-6-8-23-21(13-18)31-26(36-23)30-16-5-7-20(27)24(12-16)34-15-17-4-3-11-32(17)2/h5-10,12-14,17H,3-4,11,15H2,1-2H3,(H,28,33)(H,30,31)/t17-/m0/s1

InChi Key: KMNCFOUKJYOZIF-KRWDZBQOSA-N