Description
VEGFR-2 inhibitor is a potent inhibitor of Vascular Endothelial Growth Factor-2 Receptor Tyrosine Kinase (VEGFR-2). It shows 79% inhibition in the murine matrigel model for vascular permeability at 100 mg/kg. It shows an ED₅₀ of 16.3 mg/kg in the rat corneal angiogenesis model.
VEGFR-2 inhibitor is a potent inhibitor of Vascular Endothelial Growth Factor-2 Receptor Tyrosine Kinase (VEGFR-2). It shows 79% inhibition in the murine matrigel model for vascular permeability at 100 mg/kg. It shows an ED₅₀ of 16.3 mg/kg in the rat corneal angiogenesis model.
B2938 | VEGFR-2 inhibitor DataSheet
Alternate Name/Synonyms: 4-((2-((4-Chloro-3-((((2S)-1-methyl-2-pyrrolidinyl)methyl)oxy)-phenyl)amino)-1,3-benzoxazol-5-yl)oxy)-N-methyl-2-pyridinecarboxamide
Appearance: Solid
Formulation:
CAS Number: 769960-39-6
Structure Available?: True
Peptide sequence:
Salt Form: false
Molecular Formula: C₂₆H₂₆ClN₅O₄
Molecular Weight: 507.97
Cell-Permeable?: True
Purity: 95%
Solubilities: Soluble in in DMSO
Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Country of Origin: USA
Tag Line: An inhibitor of VEGFR-2
MDL Number:
PubChem CID:
SMILES: O=C(C1=NC=CC(OC2=CC=C(OC(NC3=CC=C(Cl)C(OC[C@H]4N(C)CCC4)=C3)=N5)C5=C2)=C1)NC
InChi: InChI=1S/C26H26ClN5O4/c1-28-25(33)22-14-19(9-10-29-22)35-18-6-8-23-21(13-18)31-26(36-23)30-16-5-7-20(27)24(12-16)34-15-17-4-3-11-32(17)2/h5-10,12-14,17H,3-4,11,15H2,1-2H3,(H,28,33)(H,30,31)/t17-/m0/s1
InChi Key: KMNCFOUKJYOZIF-KRWDZBQOSA-N
Additional Information
Storage Condition: |
-20ºC |
Shipping Condition: |
RT |
Shelf Life: |
36 months |