VEGFR-2 & tubulin inhibitor | B2932

VEGFR-2 and tubulin inhibitor inhibits polymerization of tubulin with an IC₅₀ of 1.1 μM. It inhibits the receptor tyrosine kinase VEGFR-2 in vitro and VEGFR-2 in cells with an IC₅₀ of 0.21 μM and 0.11 μM respectively. It shows an EC₅₀ of 9 nM for causing G2/M arrest in A431 cells. Mice treated with this inhibitor show less toxicity and normal pathology.

VEGFR-2 and tubulin inhibitor inhibits polymerization of tubulin with an IC₅₀ of 1.1 μM. It inhibits the receptor tyrosine kinase VEGFR-2 in vitro and VEGFR-2 in cells with an IC₅₀ of 0.21 μM and 0.11 μM respectively. It shows an EC₅₀ of 9 nM for causing G2/M arrest in A431 cells. Mice treated with this inhibitor show less toxicity and normal pathology.

B2932 | VEGFR-2 & tubulin inhibitor DataSheet

Alternate Name/Synonyms: (2,3-Dihydro-benzo[1,4]dioxin-6-yl)-(5-{2-[(pyridin-4-ylmethyl)-amino]-phenyl}-[1,3,4]oxadiazol-2-yl)-amine; Dual VEGFR-2 and tubulin inhibitor

Appearance: Solid

Formulation:

CAS Number: 830333-53-4

Structure Available?: True

Peptide sequence:

Salt Form: false

Molecular Formula: C₂₂H₁₉N₅O₃

Molecular Weight: 401.42

Cell-Permeable?: True

Purity: 95%

Solubilities: Soluble in DMSO in 0

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: A dual VEGFR-2 and tubulin inhibitor

MDL Number:

PubChem CID:

SMILES: C1(NC2=CC=C(OCCO3)C3=C2)=NN=C(C4=CC=CC=C4NCC5=CC=NC=C5)O1

InChi: InChI=1S/C22H19N5O3/c1-2-4-18(24-14-15-7-9-23-10-8-15)17(3-1)21-26-27-22(30-21)25-16-5-6-19-20(13-16)29-12-11-28-19/h1-10,13,24H,11-12,14H2,(H,25,27)

InChi Key: IQVQCEHRAJVTIU-UHFFFAOYSA-N