VER-155008 | B2413

VER-155008 is a potent heat shock protein 70 (Hsp70) inhibitor (IC₅₀ = 0.5 μM). Inhibits cell proliferation of multiple human tumor cell lines in vitro. Also binds Hsc70 and Grp78 and displays selectivity against Hsp90β (IC₅₀ >200 μM for Hsp90β). Displays potent anticancer activity.

VER-155008 is a potent heat shock protein 70 (Hsp70) inhibitor (IC₅₀ = 0.5 μM). Inhibits cell proliferation of multiple human tumor cell lines in vitro. Also binds Hsc70 and Grp78 and displays selectivity against Hsp90β (IC₅₀ >200 μM for Hsp90β). Displays potent anticancer activity.

B2413 | VER-155008 DataSheet

Alternate Name/Synonyms: 5'-O-[(4-Cyanophenyl)methyl]-8-[[(3,4-dichlorophenyl)methyl]amino]-adenosine

Appearance: White solid

Formulation:

CAS Number: 1134156-31-2

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₅H₂₃Cl₂N₇O₄

Molecular Weight: 556.4

Cell-Permeable?: True

Purity: ≥98% by HPLC

Solubilities: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: A Hsp70 inhibitor

MDL Number:

PubChem CID: 25195348

SMILES: C1=CC(=CC=C1COCC2C(C(C(O2)N3C4=C(C(=NC=N4)N)N=C3NCC5=CC(=C(C=C5)Cl)Cl)O)O)C#N

InChi: InChI=1S/C25H23Cl2N7O4/c26-16-6-5-15(7-17(16)27)9-30-25-33-19-22(29)31-12-32-23(19)34(25)24-21(36)20(35)18(38-24)11-37-10-14-3-1-13(8-28)2-4-14/h1-7,12,18,20-21,24,35-36H,9-11H2,(H,30,33)(H2,29,31,32)/t18-,20-,21-,24-/m1/s1

InChi Key: ZXGGCBQORXDVTE-UMCMBGNQSA-N