Vericiguat | B3306

Vericiguat (BAY10-21189), is a potent and orally active sGC (Soluble Guanylate Cyclase) stimulator. sGC catalyzes the formation of cyclic guanosine monophosphate (cGMP), deficiency of which is implicated in the pathogenesis of chronic kidney disease (CKD). Direct stimulation of soluble guanylate cyclase (sGC) is emerging as a potential new approach for the treatment of renal disorders

Vericiguat (BAY10-21189), is a potent and orally active sGC (Soluble Guanylate Cyclase) stimulator. sGC catalyzes the formation of cyclic guanosine monophosphate (cGMP), deficiency of which is implicated in the pathogenesis of chronic kidney disease (CKD). Direct stimulation of soluble guanylate cyclase (sGC) is emerging as a potential new approach for the treatment of renal disorders

B3306 | Vericiguat DataSheet

Alternate Name/Synonyms: methyl (4,6-diamino-2-(5-fluoro-1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl)pyrimidin-5-yl)carbamate BAY-1021189 BAY1021189

Appearance: Solid

Formulation:

CAS Number: 1350653-20-1

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₉H₁₆F₂N₈O₂

Molecular Weight: 426.39

Cell-Permeable?: TRUE

Purity: ≥98%

Solubilities: >45 mg/ml DMSO

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: A potent Soluble Guanylate Cyclase Stimulator

MDL Number:

PubChem CID: 54674461

SMILES: O=C(OC)NC1=C(N)N=C(C2=NN(CC3=CC=CC=C3F)C4=NC=C(F)C=C42)N=C1N

InChi: InChI=1S/C19H16F2N8O2/c1-31-19(30)25-14-15(22)26-17(27-16(14)23)13-11-6-10(20)7-24-18(11)29(28-13)8-9-4-2-3-5-12(9)21/h2-7H,8H2,1H3,(H,25,30)(H4,22,23,26,27)

InChi Key: QZFHIXARHDBPBY-UHFFFAOYSA-N