Vincristine sulfate | B2048

Vincristine is a plant alkaloid isolated from Vinca Rosea that irreversibly blocks mitosis by binding to tubulin (Ki = 85 nM) and inhibiting tubulin polymerization. It arrests cell cycle in G2/M-phase by blocking mitotic spindle formation. Vincristine is exported from cells via the ATP-binding cassette transporter P-glycoprotein, but not by multidrug resistance-associated protein.

Vincristine is a plant alkaloid isolated from Vinca Rosea that irreversibly blocks mitosis by binding to tubulin (Ki = 85 nM) and inhibiting tubulin polymerization. It arrests cell cycle in G2/M-phase by blocking mitotic spindle formation. Vincristine is exported from cells via the ATP-binding cassette transporter P-glycoprotein, but not by multidrug resistance-associated protein.

B2048 | Vincristine sulfate DataSheet

Alternate Name/Synonyms: 22-Oxovincaleukoblastine sulfate salt, Leurocristine sulfate salt, VCR

Appearance: White to off-white solid

Formulation: N/A

CAS Number: 2068-78-2

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₄₆H₅₆N₄O₁₀ · H₂SO₄

Molecular Weight: 923.04

Cell-Permeable?: Yes

Purity: ≥95%

Solubilities: DMSO (~5 mg/ml)

Handling: Protect from air and moisture

Country of Origin: USA

Tag Line: A tubulin polymerization inhibitor

MDL Number: MFCD00084729

PubChem CID: 249332

SMILES: CCC1(CC2CC(C3=C(CCN(C2)C1)C4=CC=CC=C4N3)(C5=C(C=C6C(=C5)C78CCN9C7C(C=CC9)(C(C(C8N6C=O)(C(=O)OC)O)OC(=O)C)CC)OC)C(=O)OC)O.OS(=O)(=O)O

InChi: InChI=1S/C46H56N4O10.H2O4S/c1-7-42(55)22-28-23-45(40(53)58-5,36-30(14-18-48(24-28)25-42)29-12-9-10-13-33(29)47-36)32-20-31-34(21-35(32)57-4)50(26-51)38-44(31)16-19-49-17-11-15-43(8-2,37(44)49)39(60-27(3)52)46(38,56)41(54)59-6;1-5(2,3)4/h9-13,15,20-21,26,28,37-39,47,55-56H,7-8,14,16-19,22-25H2,1-6H3;(H2,1,2,3,4)/t28-,37+,38-,39-,42+,43-,44-,45+,46+;/m1./s1

InChi Key: AQTQHPDCURKLKT-JKDPCDLQSA-N