Vinorelbine Tartrate | 1957

A semi-synthetic vinca alkaloid that displays potent anti-mitotic and anti-tumor properties. Its main mechanism of action is thought to be inhibition of microtubule dynamics, which results in mitotic arrest and eventual cell death. Acts as a microtubule destabilizing agent. At high concentrations, it stimulates microtubule depolymerization and mitotic spindle destruction. At lower clinically relevant concentrations, vinorelbine blocks mitotic progression. Its main targets are tubulin and microtubules. Unlike the taxanes, which bind poorly to soluble tubulin, vinorelbine can bind both soluble and microtubule-associated tubulin.

Vinorelbine Tartrate is a semi-synthetic vinca alkaloid that displays potent anti-mitotic and anti-tumor properties. Its main mechanism of action is thought to be inhibition of microtubule dynamics, which results in mitotic arrest and eventual cell death. Acts as a microtubule destabilizing agent.

1957 | Vinorelbine Tartrate DataSheet

Alternate Name/Synonyms: 3′,4′-Didehydro-4′-deoxy-C′-norvincaleukoblastine [R-(R*,R*)-2-3-dihydroxybutanedioate (1:2)salt], 5′-Noranhydrovinoblastine tartrate, KW-2307, NVB, Navelbine tartrate

Appearance: Off-white solid

Formulation: N/A

CAS Number: 125317-39-7

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₄₅H₅₄N₄O₈.C₈H₁₂O₁₂

Molecular Weight: 1079.11

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: Water (~ 10 mg/ml)

Handling: Protect from light and moisture

Country of Origin: USA

Tag Line: An anti-mitotic and antitumor agent

MDL Number: MFCD03613607

PubChem CID: 607791

SMILES: CCC1=CC2CC(C3=C(CN(C2)C1)C4=CC=CC=C4N3)(C5=C(C=C6C(=C5)C78CCN9C7C(C=CC9) (C(C(C8N6C)(C(=O)OC)O)OC(=O)C)CC)OC)C(=O)OC.C(C(C(=O)O)O)(C(=O)O)O.C(C(C (=O)O)O)(C(=O)O)O

InChi: InChI=1S/C45H54N4O8.2C4H6O6/c1-8-27-19-28-22-44(40(51)55-6, 36-30(25-48(23-27)24-28)29-13-10-11-14-33(29)46-36)32-20-31-34(21-35(32) 54-5)47(4)38-43(31)16-18-49-17-12-15-42(9-2, 37(43)49)39(57-26(3)50)45(38, 53)41(52)56-7;2*5-1(3(7)8)2(6)4(9)10/h10-15,19-21,28,37-39,46,53H,8-9, 16-18,22-25H2,1-7H3;2*1-2,5-6H,(H,7,8)(H,9,10)/t28?,37-,38+,39+,42+,43+, 44-,45-;2*1-,2-/m011/s1

InChi Key: CILBMBUYJCWATM-NPJYPKOYSA-N