Vitronectin, Human Plasma | 4087

Vitronectin and plasminogen activator inhibitor type 1 are proteins that interact in the circulatory system and pericellular region to regulate fibrinolysis, cell adhesion, and migration. Plasminogen activator inhibitor type 1, a serine proteinase, through its binding to the plasma protein vitronectin, influences processes that are key regulators of hemostatic process, for example, thrombosis and wound healing. In addition, the vitronectin and plasminogen activator inhibitor type 1 complex regulates binding of blood platelets and cells to extracellular substrata in events like tumor metastasis. The plasma concentration of vitronectin is 200 to 400 g/ml.

4087 | Vitronectin Human Plasma DataSheet

Biomolecule/Target: Vitronectin

Synonyms: S- protein, Serum-spreading factor, V75

Alternates names: S- protein, Serum-spreading factor, V75

Taglines: A glycoprotein promoting cell adhesion and spreading

NCBI Gene ID #: 3952

NCBI Gene Symbol: LEP

Gene Source: Human

Accession #: P41159

Recombinant: No

Source: Human plasma

Purity by SDS-PAGEs: 98%

Assay: SDS-PAGE

Purity: N/A

Assay #2: HPLC

Endotoxin Level: N/A

Activity (Specifications/test method): N/A

Biological activity: ’s human Leptin has been shown to be biologically active in two different mouse obesity models, ob/ob and NZO. Both strains of mice were treated via intraperitoneal injection once daily at a dose of 5 mg Leptin/gm of body weight for 7 days. Significant effects on body weight, food consumption, and plasma glucose levels were observed to saline-treated controls.

Results: N/A

Binding Capacity: N/A

Unit Definition: N/A

Molecular Weight: 16.0 kDa

Concentration: 200 to 400 g/ml

Appearance: Lyophilized protein

Physical form description: Lyophilized from 10 mM sodium phosphate, pH 7.7

Reconstitution Instructions: Add 15 mM sterile HCl (0.5 ml/1 mg vial or 5 ml/10 mg vial) to the vial. After the protein is completely dissolved, add 7.5 mM sterile NaOH (0.3 ml/1 mg vial or 3 ml/10 mg vial) to bring the pH to approximately 5.2.

Amino acid sequence: N/A