Description
VLX600 is a small molecule which is cytotoxic to quiescent cells in colon cancer cells with an IC₅₀ of 1-10 μM. VLX600 decreases mitochondrial oxidative phosphorylation and shows enhanced cytotoxic activity under conditions of nutrient starvation. It inhibits growth of colon cancer xenografts with minimal systemic toxicity in mice.
VLX600 is a small molecule which is cytotoxic to quiescent cells in colon cancer cells with an IC₅₀ of 1-10 μM. VLX600 decreases mitochondrial oxidative phosphorylation and shows enhanced cytotoxic activity under conditions of nutrient starvation. It inhibits growth of colon cancer xenografts with minimal systemic toxicity in mice.
Alternate Name/Synonyms: 6-methyl-N-[(E)-1-pyridin-2-ylethylideneamino]-5H-[1,2,4]triazino[5,6-b]indol-3-amine; 6-Methyl-3-((2E)-2-(1-(pyridin-2-yl)ethylidene)hydrazinyl)-5H-(1,2,4)triazino(5,6-b)indole; Ethanone, 1-(2-pyridinyl)-, 2-(6-methyl-5H-1,2,4-triazino(5,6-b)indol-3-yl)hydrazone
Appearance: A crystalline solid
Formulation:
CAS Number: 327031-55-0
Structure Available?: True
Peptide sequence:
Salt Form: false
Molecular Formula: C₁₇H₁₅N₇
Molecular Weight: 317.35
Cell-Permeable?: True
Purity: ≥95%
Solubilities: ~1 mg/ml in in Ethanol, ~20 mg/ml in DMSO and DMF in 0
Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Country of Origin: USA
Tag Line: A small molecule which is cytotoxic to quiescent cancer cells
MDL Number:
PubChem CID: 6410104
SMILES: CC1=C2C(=CC=C1)C3=C(N2)N=C(N=N3)NN=C(C)C4=CC=CC=N4
InChi: InChI=1S/C17H15N7/c1-10-6-5-7-12-14(10)19-16-15(12)22-24-17(20-16)23-21-11(2)13-8-3-4-9-18-13/h3-9H,1-2H3,(H2,19,20,23,24)/b21-11+
InChi Key: UQOSBPRTQFFUOA-SRZZPIQSSA-N
Additional Information
Storage Condition: |
-20ºC |
Shipping Condition: |
RT |
Shelf Life: |
36 months |