VLX600 | B2849

VLX600 is a small molecule which is cytotoxic to quiescent cells in colon cancer cells with an IC₅₀ of 1-10 μM. VLX600 decreases mitochondrial oxidative phosphorylation and shows enhanced cytotoxic activity under conditions of nutrient starvation. It inhibits growth of colon cancer xenografts with minimal systemic toxicity in mice.

VLX600 is a small molecule which is cytotoxic to quiescent cells in colon cancer cells with an IC₅₀ of 1-10 μM. VLX600 decreases mitochondrial oxidative phosphorylation and shows enhanced cytotoxic activity under conditions of nutrient starvation. It inhibits growth of colon cancer xenografts with minimal systemic toxicity in mice.

B2849 | VLX600 DataSheet

Alternate Name/Synonyms: 6-methyl-N-[(E)-1-pyridin-2-ylethylideneamino]-5H-[1,2,4]triazino[5,6-b]indol-3-amine; 6-Methyl-3-((2E)-2-(1-(pyridin-2-yl)ethylidene)hydrazinyl)-5H-(1,2,4)triazino(5,6-b)indole; Ethanone, 1-(2-pyridinyl)-, 2-(6-methyl-5H-1,2,4-triazino(5,6-b)indol-3-yl)hydrazone

Appearance: A crystalline solid

Formulation:

CAS Number: 327031-55-0

Structure Available?: True

Peptide sequence:

Salt Form: false

Molecular Formula: C₁₇H₁₅N₇

Molecular Weight: 317.35

Cell-Permeable?: True

Purity: ≥95%

Solubilities: ~1 mg/ml in in Ethanol, ~20 mg/ml in DMSO and DMF in 0

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: A small molecule which is cytotoxic to quiescent cancer cells

MDL Number:

PubChem CID: 6410104

SMILES: CC1=C2C(=CC=C1)C3=C(N2)N=C(N=N3)NN=C(C)C4=CC=CC=N4

InChi: InChI=1S/C17H15N7/c1-10-6-5-7-12-14(10)19-16-15(12)22-24-17(20-16)23-21-11(2)13-8-3-4-9-18-13/h3-9H,1-2H3,(H2,19,20,23,24)/b21-11+

InChi Key: UQOSBPRTQFFUOA-SRZZPIQSSA-N