Vonoprazan fumarate | B2292

Vonoprazan fumarate is a Potassium-competitive acid blocker (P-CAB) that inhibits gastric H⁺/K⁺ATPase (IC₅₀ = 17 nM) but does not inhibit porcine Na+/K+ ATPase activity when used at a concentration of 10 µM.

Vonoprazan fumarate is a Potassium-competitive acid blocker (P-CAB) that inhibits gastric H⁺/K⁺ATPase (IC₅₀ = 17 nM) but does not inhibit porcine Na+/K+ ATPase activity when used at a concentration of 10 µM.

B2292 | Vonoprazan fumarate DataSheet

Alternate Name/Synonyms: 1-(5-(2-fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-yl)-N-methylmethanamine fumarate; TAK-438

Appearance: Crystalline solid

Formulation: N/A

CAS Number: 1260141-27-2

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₇H₁₆FN₃O₂S • C₄H₄O₄

Molecular Weight: 461.5

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A Potassium-competitive acid blocker (P-CAB) that inhibits gastric H⁺/K⁺ATPase

MDL Number: N/A

PubChem CID: 45375887

SMILES: CNCC1=CN(C(=C1)C2=CC=CC=C2F)S(=O)(=O)C3=CN=CC=C3.C(=CC(=O)O)C(=O)O

InChi: InChI=1S/C17H16FN3O2S.C4H4O4/c1-19-10-13-9-17(15-6-2-3-7-16(15)18)21(12-13)24(22,23)14-5-4-8-20-11-14;5-3(6)1-2-4(7)8/h2-9,11-12,19H,10H2,1H3;1-2H,(H,5,6)(H,7,8)/b;2-1+

InChi Key: ROGSHYHKHPCCJW-WLHGVMLRSA-N