VS-5584 | 9603

VS-5584 is a potent and selective PI3K/mTOR kinase inhibitor. It inhibits mTOR (IC₅₀ = 37 nM) and PI3K (IC₅₀s = 16, 68, 25, and 42 nM for the α, β, γ, and δ isoforms, respectively) without relevant activity against more than 400 additional lipid and protein kinases. Also acts as a cancer stem cell inhibitor

VS-5584 is a potent and selective PI3K/mTOR kinase inhibitor. It inhibits mTOR (IC₅₀ = 37 nM) and PI3K (IC₅₀s = 16, 68, 25, and 42 nM for the α, β, γ, and δ isoforms, respectively) without relevant activity against more than 400 additional lipid and protein kinases. Also acts as a cancer stem cell inhibitor

9603 | VS-5584 DataSheet

Alternate Name/Synonyms: 5-(8-methyl-2-morpholin-4-yl-9-propan-2-ylpurin-6-yl)pyrimidin-2-amine; SB2343

Appearance: Crystalline solid

Formulation: N/A

CAS Number: 1246560-33-7

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₇H₂₂N₈O

Molecular Weight: 354.41

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (~15 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A potent and selective PI3K/mTOR kinase inhibitor

MDL Number: N/A

PubChem CID: 46912230

SMILES: CC1=NC2=C(N=C(N=C2N1C(C)C)N3CCOCC3)C4=CN=C(N=C4)N

InChi: InChI=1S/C17H22N8O/c1-10(2)25-11(3)21-14-13(12-8-19-16(18)20-9-12)22-17(23-15(14)25)24-4-6-26-7-5-24/h8-10H,4-7H2,1-3H3,(H2,18,19,20)

InChi Key: QYBGBLQCOOISAR-UHFFFAOYSA-N