Description
VU 0361737 is a selective, brain-permeable, positive allosteric modulator at mGlu4 receptors (EC₅₀ values are 240 and 110 nM at human and rat receptors respectively). Inactive at mGlu1, mGlu2, mGlu3, mGlu6 and mGlu7 receptors and displays weak activity at mGlu5 and mGlu8 receptors.
VU 0361737 is a selective, brain-permeable, positive allosteric modulator at mGlu4 receptors (EC₅₀ values are 240 and 110 nM at human and rat receptors respectively). Inactive at mGlu1, mGlu2, mGlu3, mGlu6 and mGlu7 receptors and displays weak activity at mGlu5 and mGlu8 receptors.
Alternate Name/Synonyms: N-(4-Chloro-3-methoxyphenyl)-2-pyridinecarboxamide
Appearance: Off-white solid
Formulation: N/A
CAS Number: 1161205-04-4
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₁₃H₁₁ClN₂O₂
Molecular Weight: 262.69
Cell-Permeable?: Yes
Purity: ≥98% by HPLC
Solubilities: DMSO (>20 mg/ml)
Handling: Protect from air and light
Country of Origin: USA
Tag Line: A positive allosteric modulator at mGlu4 receptors
MDL Number: N/A
PubChem CID: 44191096
SMILES: COC1=C(C=CC(=C1)NC(=O)C2=CC=CC=N2)Cl
InChi: InChI=1S/C13H11ClN2O2/c1-18-12-8-9(5-6-10(12)14)16-13(17)11-4-2-3-7-15-11/h2-8H,1H3,(H,16,17)
InChi Key: ARYUXFNGXHNNDM-UHFFFAOYSA-N
Additional Information
Storage Condition: |
-20°C |
Shipping Condition: |
Gel Pack |
Shelf Life: |
36 months |