VU0361737 | 9418

VU 0361737 is a selective, brain-permeable, positive allosteric modulator at mGlu4 receptors (EC₅₀ values are 240 and 110 nM at human and rat receptors respectively). Inactive at mGlu1, mGlu2, mGlu3, mGlu6 and mGlu7 receptors and displays weak activity at mGlu5 and mGlu8 receptors.

VU 0361737 is a selective, brain-permeable, positive allosteric modulator at mGlu4 receptors (EC₅₀ values are 240 and 110 nM at human and rat receptors respectively). Inactive at mGlu1, mGlu2, mGlu3, mGlu6 and mGlu7 receptors and displays weak activity at mGlu5 and mGlu8 receptors.

9418 | VU0361737 DataSheet

Alternate Name/Synonyms: N-(4-Chloro-3-methoxyphenyl)-2-pyridinecarboxamide

Appearance: Off-white solid

Formulation: N/A

CAS Number: 1161205-04-4

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₃H₁₁ClN₂O₂

Molecular Weight: 262.69

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (>20 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A positive allosteric modulator at mGlu4 receptors

MDL Number: N/A

PubChem CID: 44191096

SMILES: COC1=C(C=CC(=C1)NC(=O)C2=CC=CC=N2)Cl

InChi: InChI=1S/C13H11ClN2O2/c1-18-12-8-9(5-6-10(12)14)16-13(17)11-4-2-3-7-15-11/h2-8H,1H3,(H,16,17)

InChi Key: ARYUXFNGXHNNDM-UHFFFAOYSA-N