WAY-265497 | B2936

WAY-265497 is a potent ATP-binding site-targeting inhibitor of Cdk4/D1 kinase activity with an IC₅₀ of 30 nM. It inhibits HCT116 and MCF-7 cancer cells with IC₅₀ values of 0.73 and 0.88 µM, respectively. It inhibits Cdk2/E and Cdk1/B at higher concentrations with IC₅₀ values of 1.6 µM and 25.3 µM, respectively.

WAY-265497 is a potent ATP-binding site-targeting inhibitor of Cdk4/D1 kinase activity with an IC₅₀ of 30 nM. It inhibits HCT116 and MCF-7 cancer cells with IC₅₀ values of 0.73 and 0.88 µM, respectively. It inhibits Cdk2/E and Cdk1/B at higher concentrations with IC₅₀ values of 1.6 µM and 25.3 µM, respectively.

B2936 | WAY-265497 DataSheet

Alternate Name/Synonyms: 4-[[[(4-Hydroxy-5-propoxy-2-pyridinyl)methyl]amino]methylene]-6-iodo-1,3(2H,4H)-isoquinolinedione; Cdk4 Inhibitor V

Appearance: Solid

Formulation:

CAS Number: 943746-57-4

Structure Available?: True

Peptide sequence:

Salt Form: false

Molecular Formula: C₁₉H₁₈IN₃O₄

Molecular Weight: 479.27

Cell-Permeable?: True

Purity: 95%

Solubilities: 50 mg/ml in in DMSO

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: An inhibitor of Cdk4

MDL Number:

PubChem CID:

SMILES: O=C1NC(/C(C2=C1C=CC(I)=C2)=C\NCC3=NC=C(OCCC)C(O)=C3)=O

InChi: InChI=1S/C19H18IN3O4/c1-2-5-27-17-10-22-12(7-16(17)24)8-21-9-15-14-6-11(20)3-4-13(14)18(25)23-19(15)26/h3-4,6-7,9-10,21H,2,5,8H2,1H3,(H,22,24)(H,23,25,26)/b15-9-

InChi Key: DXMZEMWEDCPBNA-DHDCSXOGSA-N