Description
Wedelolactone is a natural coumestan that irreversibly inhibits IKK in NF-κB signaling pathway. IKK phosphorylates the IκBα protein, which results in the degradation and dissociation of IκBα from NF-κB leading to NF-κB activation. Wedelolactone has anti-inflammatory effect through inhibiting IKK activity and caspase-11 expression. It improves lipid metabolism partly by AMPK activation and up-regulation of expression of PPARα/Lipopoptein Lipase and Low Density Lipoprotein Receptor.
Wedelolactone is a natural coumestan that irreversibly inhibits IKK in NF-κB signaling pathway. IKK phosphorylates the IκBα protein, which results in the degradation and dissociation of IκBα from NF-κB leading to NF-κB activation. Wedelolactone has anti-inflammatory effect through inhibiting IKK activity and caspase-11 expression. It improves lipid metabolism partly by AMPK activation and up-regulation of expression of PPARα/Lipopoptein Lipase and Low Density Lipoprotein Receptor.
B2811 | Wedelolactone DataSheet
Alternate Name/Synonyms: 7-Methoxy-5,11,12-trihydroxy-coumestan, 1,8,9-Trihydroxy-3-methoxycoumestan, 1,8,9-Trihydroxy-3-methoxy-6H-[1]benzofuro[3,2-c]chromen-6-one 1,8,9-trihydroxy-3-methoxy-6H-benzofuro[3,2-c][1]benzopyran-6-one, IKK inhibitor
Appearance: Crystalline solid
Formulation:
CAS Number: 524-12-9
Structure Available?: True
Peptide sequence:
Salt Form: False
Molecular Formula: C₁₆H₁₀O₇
Molecular Weight: 314.25
Cell-Permeable?: True
Purity: >98%
Solubilities: ~20 mg/ml in in Ethanol, ~30 mg/ml in DMSO and DMF in 0
Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Country of Origin: USA
Tag Line: A natural coumestan that inhibits IKK in NF-κB signaling pathway
MDL Number:
PubChem CID: 5281813
SMILES: COC1=CC(=C2C(=C1)OC(=O)C3=C2OC4=CC(=C(C=C43)O)O)O
InChi: InChI=1S/C16H10O7/c1-21-6-2-10(19)14-12(3-6)23-16(20)13-7-4-8(17)9(18)5-11(7)22-15(13)14/h2-5,17-19H,1H3
InChi Key: XQDCKJKKMFWXGB-UHFFFAOYSA-N
Additional Information
Storage Condition: |
-20ºC |
Shipping Condition: |
Gel Pack |
Shelf Life: |
36 months |