Wedelolactone | B2811

Wedelolactone is a natural coumestan that irreversibly inhibits IKK in NF-κB signaling pathway. IKK phosphorylates the IκBα protein, which results in the degradation and dissociation of IκBα from NF-κB leading to NF-κB activation. Wedelolactone has anti-inflammatory effect through inhibiting IKK activity and caspase-11 expression. It improves lipid metabolism partly by AMPK activation and up-regulation of expression of PPARα/Lipopoptein Lipase and Low Density Lipoprotein Receptor.

Wedelolactone is a natural coumestan that irreversibly inhibits IKK in NF-κB signaling pathway. IKK phosphorylates the IκBα protein, which results in the degradation and dissociation of IκBα from NF-κB leading to NF-κB activation. Wedelolactone has anti-inflammatory effect through inhibiting IKK activity and caspase-11 expression. It improves lipid metabolism partly by AMPK activation and up-regulation of expression of PPARα/Lipopoptein Lipase and Low Density Lipoprotein Receptor.

B2811 | Wedelolactone DataSheet

Alternate Name/Synonyms: 7-Methoxy-5,11,12-trihydroxy-coumestan, 1,8,9-Trihydroxy-3-methoxycoumestan, 1,8,9-Trihydroxy-3-methoxy-6H-[1]benzofuro[3,2-c]chromen-6-one 1,8,9-trihydroxy-3-methoxy-6H-benzofuro[3,2-c][1]benzopyran-6-one, IKK inhibitor

Appearance: Crystalline solid

Formulation:

CAS Number: 524-12-9

Structure Available?: True

Peptide sequence:

Salt Form: False

Molecular Formula: C₁₆H₁₀O₇

Molecular Weight: 314.25

Cell-Permeable?: True

Purity: >98%

Solubilities: ~20 mg/ml in in Ethanol, ~30 mg/ml in DMSO and DMF in 0

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: A natural coumestan that inhibits IKK in NF-κB signaling pathway

MDL Number:

PubChem CID: 5281813

SMILES: COC1=CC(=C2C(=C1)OC(=O)C3=C2OC4=CC(=C(C=C43)O)O)O

InChi: InChI=1S/C16H10O7/c1-21-6-2-10(19)14-12(3-6)23-16(20)13-7-4-8(17)9(18)5-11(7)22-15(13)14/h2-5,17-19H,1H3

InChi Key: XQDCKJKKMFWXGB-UHFFFAOYSA-N