WH-4-023 | 2827

WH-4-023 is a potent and selective dual Lck/Src inhibitor with IC₅₀ of 2 nM and 6 nM for Lck and Src kinase respectively; little inhibition on p38α and KDR.

WH-4-023 is a potent and selective dual Lck/Src inhibitor with IC₅₀ of 2 nM and 6 nM for Lck and Src kinase respectively; little inhibition on p38α and KDR.

2827 | WH-4-023 DataSheet

Alternate Name/Synonyms: 2,6-dimethylphenyl (2,4-dimethoxyphenyl)(2-((4-(4-methylpiperazin-1-yl)phenyl)amino)pyrimidin-4-yl)carbamate

Appearance: Off-white solid

Formulation: N/A

CAS Number: 837422-57-8

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₃₂H₃₆N₆O₄

Molecular Weight: 568.67

Cell-Permeable?: yes

Purity: ≥98% by HPLC

Solubilities: DMSO (>50 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A potent and selective dual Lck/Src inhibitor

MDL Number: N/A

PubChem CID: 11844351

SMILES: CC1=C(C(=CC=C1)C)OC(=O)N(C2=C(C=C(C=C2)OC)OC)C3=NC(=NC=C3)NC4=CC=C(C=C4)N5CCN(CC5)C

InChi: InChI=1S/C32H36N6O4/c1-22-7-6-8-23(2)30(22)42-32(39)38(27-14-13-26(40-4)21-28(27)41-5)29-15-16-33-31(35-29)34-24-9-11-25(12-10-24)37-19-17-36(3)18-20-37/h6-16,21H,17-20H2,1-5H3,(H,33,34,35)

InChi Key: NBTNHSGBRGTFJS-UHFFFAOYSA-N