WHI-P154 | 2659

WHI-P154 is a potent JAK3 inhibitor (IC₅₀ of 1.8 μM). It displays no activity against JAK1 or JAK2. Also inhibits EGFR, Src, Abl, VEGFR and MAPK, and prevents Stat3, but not Stat5 phosphorylation. Induces differentiation of neural progenitor cells

WHI-P154 is a potent JAK3 inhibitor (IC₅₀ of 1.8 μM). It displays no activity against JAK1 or JAK2. Also inhibits EGFR, Src, Abl, VEGFR and MAPK, and prevents Stat3, but not Stat5 phosphorylation. Induces differentiation of neural progenitor cells

2659 | WHI-P154 DataSheet

Alternate Name/Synonyms: 2-Bromo-4-[(6,7-dimethoxy-4-quinazolinyl)amino]phenol

Appearance: White to off-white solid

Formulation: N/A

CAS Number: 211555-04-3

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₆H₁₄BrN₃O₃

Molecular Weight: 376.2

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (>35 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A potent JAK3 inhibitor

MDL Number: N/A

PubChem CID: 3795

SMILES: COC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC(=C(C=C3)O)Br)OC

InChi: InChI=1S/C16H14BrN3O3/c1-22-14-6-10-12(7-15(14)23-2)18-8-19-16(10)20-9-3-4-13(21)11(17)5-9/h3-8,21H,1-2H3,(H,18,19,20)

InChi Key: CBIAKDAYHRWZCU-UHFFFAOYSA-N